Dendric spine loss associated with schizophrenia, bipolar disorder

Dendritic spine loss has been linked to both schizophrenia and bipolar disorder, suggesting that the two disorders could share common pathophysiological features, according to research published in JAMA Psychiatry.

Dendritic spines are small membrane-like protrusions from a neuron's dendrite that help to transmit signals to the neuron's cell body.

Previous studies have found that schizophrenia patients sometimes show spine loss in the dorsolateral prefrontal cortices.

Spine density in schizophrenia patients

Researchers analyzed the brain tissue in postmortem individuals: 14 with schizophrenia, 9 with bipolar disorder and 19 control patients.

The average spine density was reduced by 10.5 percent in individuals who had bipolar disorder and by 6.5 percent in schizophrenia patients, compared with the control subjects.

The average number of spines per dendrite was also lower in subjects who had schizophrenia or bipolar disorder than in control subjects.

"The current study suggests that spine pathology is common to both [schizophrenia] and [bipolar disorder]," the study authors stated. "Moreover, the study of the mechanisms underlying the spine pathology might reveal additional similarities and differences between the two disorders, which could lead to the development of novel biomarkers and therapeutics."

Source: The JAMA Network Journals

More Articles

Creatine is a type of acid naturally manufactured by our liver, pancreas and kidneys. One of its primary roles in the body is to provide energy...

There are two commonly used sets of criteria for diagnosing schizophrenia and other mental health disorders: the Diagnostic and Statistical Manual...

There are a number of talented musicians who have suffered from schizophrenia at some point in...

People in the prodromal phase of schizophrenic experience what can be called...

The term "schizophrenic break" refers to an episode of acute psychosis in someone with...

More Articles

More Articles

Creatine is a type of acid naturally manufactured by our liver, pancreas and kidneys. One of its primary roles in the body is to provide energy...

There are two commonly used sets of criteria for diagnosing schizophrenia and other mental health disorders: the Diagnostic and Statistical Manual...

There are a number of talented musicians who have suffered from schizophrenia at some point in...

People in the prodromal phase of schizophrenic experience what can be called...

The term "schizophrenic break" refers to an episode of acute psychosis in someone with...

Treating schizophrenia with medication often yields positive results. Nowadays, there are many...

Understanding the pathophysiology of schizophrenia (or, in other words, the physiological...

Scientists have been studying schizophrenia for a long time, trying to determine what...

An estimated 30% of people with schizophrenia have refractory schizophrenia, which means their...

While most people can’t fathom purposely hurting themselves, self-injury is not uncommon with certain types of psychiatric disorders. Although it...

Although schizophrenia goes back several thousand years, this most serious of psychiatric disorders was not officially coined “schizophrenia”...

The neurotransmitter serotonin is known to influence a number of important brain functions, including perception, mood, sleep, appetite, cognition...

There are a number of different research methods used in psychology, but one of the most interesting to the layperson is the case study. Case...

The question of whether people with schizophrenia know they are ill is actually quite...

No one knows exactly what causes schizophrenia, and there are a number of...