Mixed Success in Treating Schizophrenia with Antipsychotics

Why do certain popular antipsychotic drugs have mixed success in treating schizophrenia? In a new study reported from the journal, Nature Neuroscience, scientists delve into the causes for resistance to certain antipsychotic medications.

Researchers at Mount Sinai School of Medicine discovered that, over time, an enzyme in the brains of schizophrenic patients begins to compensate for the prolonged chemical changes caused by antipsychotics, resulting in reduced efficacy of the drugs.

An enzyme called HDAC2 was highly expressed in the brains of mice chronically treated with antipsychotic drugs, resulting in lower expression of the receptor called mGlu2. A recurrence of psychotic symptoms was also noted. When studying postmortem brains of schizophrenic patients, a similar finding was observed.

Scientists were able to improve the therapeutic effects of atypical antipsychotics in mouse models by administering a chemical called suberoylanilide hydroxamic acid (SAHA), which inhibits HDACs.

Javier Gonzalez-Maeso, Ph.D., lead investigator on the study, is now developing compounds with his team that specifically inhibit HDAC2, and act as additional treatments to antipsychotics.

More Articles

Treating schizophrenia with medication often yields positive results. Nowadays, there are many...

An estimated 30% of people with schizophrenia have refractory schizophrenia, which means their...

Understanding the pathophysiology of schizophrenia (or, in other words, the physiological...

There are a number of talented musicians who have suffered from schizophrenia at some point in...

While most people can’t fathom purposely hurting themselves, self-injury is not uncommon with certain types of psychiatric disorders. Although it...

More Articles

More Articles

Treating schizophrenia with medication often yields positive results. Nowadays, there are many...

An estimated 30% of people with schizophrenia have refractory schizophrenia, which means their...

Understanding the pathophysiology of schizophrenia (or, in other words, the physiological...

There are a number of talented musicians who have suffered from schizophrenia at some point in...

While most people can’t fathom purposely hurting themselves, self-injury is not uncommon with certain types of psychiatric disorders. Although it...

Although schizophrenia goes back several thousand years, this most serious of psychiatric disorders was not officially coined “schizophrenia”...

It is not uncommon for people with schizophrenia to exhibit abnormal movements. These may include rocking, pacing, posturing, strange mannerisms,...

There are two commonly used sets of criteria for diagnosing schizophrenia and other mental health disorders: the Diagnostic and Statistical Manual...

The neurotransmitter serotonin is known to influence a number of important brain functions, including perception, mood, sleep, appetite, cognition...

There are a number of different research methods used in psychology, but one of the most interesting to the layperson is the case study. Case...

The question of whether people with schizophrenia know they are ill is actually quite...

The term "schizophrenic break" refers to an episode of acute psychosis in someone with...

Creatine is a type of acid naturally manufactured by our liver, pancreas and kidneys. One of its primary roles in the body is to provide energy...

No one knows exactly what causes schizophrenia, and there are a number of...

Acute schizophrenia is what most people think of when they think of schizophrenia: varying...